Toxic leukoencephalopathy: Which Medications Cause It? (679 Reports Across 61 Drugs)
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Toxic leukoencephalopathy has been reported as an adverse event with 61 different drugs in the FDA's FAERS database, with 679 total reports. 109 of these reports resulted in death.The drugs most commonly associated with Toxic leukoencephalopathy are OXYCODONE, METHOTREXATE, and FLUOROURACIL.
679
Total Reports
61
Drugs Involved
109
Deaths
454
Hospitalizations
35.6 yrs
Average Patient Age
48.8% / 51.2%
Female / Male
Which Drugs Cause Toxic leukoencephalopathy Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| OXYCODONE | 122 | 0.1% | 42 | 96 | 34 |
| METHOTREXATE | 82 | 0.0% | 5 | 42 | 12 |
| FLUOROURACIL | 58 | 0.1% | 2 | 37 | 6 |
| FENTANYL | 51 | 0.1% | 3 | 35 | 15 |
| CAPECITABINE | 45 | 0.1% | 0 | 29 | 11 |
| CYCLOSPORINE | 44 | 0.1% | 9 | 14 | 1 |
| FLUDARABINE | 43 | 0.2% | 24 | 14 | 7 |
| MORPHINE | 42 | 0.0% | 13 | 29 | 9 |
| OXALIPLATIN | 42 | 0.1% | 0 | 32 | 7 |
| METHADONE | 35 | 0.1% | 11 | 32 | 10 |
| COCAINE | 34 | 0.2% | 23 | 30 | 8 |
| QUETIAPINE | 33 | 0.1% | 20 | 31 | 15 |
| CYTARABINE | 29 | 0.1% | 5 | 11 | 9 |
| TACROLIMUS | 22 | 0.0% | 0 | 19 | 7 |
| RITUXIMAB | 20 | 0.0% | 0 | 12 | 6 |
| CYCLOPHOSPHAMIDE | 19 | 0.0% | 3 | 16 | 0 |
| METRONIDAZOLE | 19 | 0.1% | 3 | 16 | 1 |
| DOXORUBICIN | 18 | 0.0% | 2 | 15 | 1 |
| LEUCOVORIN | 17 | 0.1% | 0 | 12 | 2 |
| BEVACIZUMAB | 16 | 0.0% | 0 | 12 | 1 |