Uterine perforation: Which Medications Cause It? (6,200 Reports Across 12 Drugs)
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Uterine perforation has been reported as an adverse event with 12 different drugs in the FDA's FAERS database, with 6,200 total reports. 7 of these reports resulted in death.The drugs most commonly associated with Uterine perforation are LEVONORGESTREL, MIRENA, and COPPER.
6,200
Total Reports
12
Drugs Involved
7
Deaths
2,759
Hospitalizations
29.6 yrs
Average Patient Age
100.0% / 0.0%
Female / Male
Which Drugs Cause Uterine perforation Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| LEVONORGESTREL | 4,973 | 4.3% | 4 | 2,294 | 383 |
| MIRENA | 644 | 17.1% | 0 | 395 | 40 |
| COPPER | 502 | 1.3% | 0 | 32 | 4 |
| PARAGARD 380A | 17 | 0.9% | 0 | 2 | 0 |
| DEVICE | 6 | 0.1% | 0 | 1 | 0 |
| LENVATINIB | 6 | 0.0% | 3 | 5 | 2 |
| PEMBROLIZUMAB | 6 | 0.0% | 3 | 4 | 2 |
| CISPLATIN | 5 | 0.0% | 0 | 5 | 0 |
| METHOTREXATE | 5 | 0.0% | 0 | 4 | 0 |
| MISOPROSTOL | 5 | 0.1% | 0 | 2 | 1 |
| NAPROXEN | 5 | 0.0% | 0 | 1 | 0 |
| TOCILIZUMAB | 5 | 0.0% | 0 | 1 | 0 |