Wernicke's encephalopathy: Which Medications Cause It? (475 Reports Across 69 Drugs)
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Wernicke's encephalopathy has been reported as an adverse event with 69 different drugs in the FDA's FAERS database, with 475 total reports. 40 of these reports resulted in death.The drugs most commonly associated with Wernicke's encephalopathy are FUROSEMIDE, METHOTREXATE, and CYCLOPHOSPHAMIDE.
475
Total Reports
69
Drugs Involved
40
Deaths
311
Hospitalizations
50.0 yrs
Average Patient Age
46.7% / 53.3%
Female / Male
Which Drugs Cause Wernicke's encephalopathy Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| FUROSEMIDE | 53 | 0.1% | 2 | 35 | 1 |
| METHOTREXATE | 43 | 0.0% | 7 | 19 | 5 |
| CYCLOPHOSPHAMIDE | 38 | 0.0% | 7 | 19 | 4 |
| TACROLIMUS | 37 | 0.0% | 0 | 12 | 0 |
| VINCRISTINE | 36 | 0.1% | 5 | 14 | 6 |
| FLUOROURACIL | 28 | 0.1% | 3 | 14 | 0 |
| CYTARABINE | 27 | 0.1% | 7 | 14 | 6 |
| OMEPRAZOLE | 27 | 0.0% | 0 | 19 | 6 |
| METFORMIN | 24 | 0.0% | 0 | 20 | 0 |
| METRONIDAZOLE | 21 | 0.1% | 5 | 16 | 5 |
| ETOPOSIDE | 18 | 0.0% | 3 | 6 | 3 |
| CYCLOSPORINE | 16 | 0.0% | 1 | 10 | 0 |
| DEXTROSE | 16 | 0.4% | 2 | 10 | 1 |
| CARBOPLATIN | 15 | 0.0% | 0 | 6 | 0 |
| PREDNISOLONE | 15 | 0.0% | 0 | 8 | 3 |
| EVEROLIMUS | 14 | 0.0% | 0 | 6 | 0 |
| ASPARAGINASE | 13 | 0.3% | 4 | 4 | 5 |
| DIAZEPAM | 13 | 0.0% | 0 | 10 | 3 |
| RITUXIMAB | 13 | 0.0% | 0 | 12 | 2 |
| SEMAGLUTIDE | 13 | 0.0% | 0 | 8 | 1 |