Bruton's Tyrosine Kinase Inhibitors [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Off label use | 397 | 2 | 45 | 120 | 15 |
| Disease progression | 265 | 2 | 50 | 36 | 4 |
| Death | 185 | 2 | 178 | 19 | 4 |
| Contusion | 171 | 2 | 3 | 23 | 4 |
| Fatigue | 158 | 2 | 14 | 35 | 3 |
| Myelosuppression | 147 | 1 | 4 | 68 | 14 |
| Rash | 142 | 2 | 5 | 20 | 1 |
| Pneumonia | 141 | 2 | 47 | 88 | 10 |
| Anaemia | 129 | 2 | 20 | 33 | 7 |
| Platelet count decreased | 128 | 2 | 20 | 49 | 13 |
| White blood cell count decreased | 119 | 1 | 9 | 37 | 5 |
| Diarrhoea | 111 | 2 | 15 | 26 | 2 |
| Drug ineffective | 107 | 2 | 28 | 33 | 4 |
| Covid-19 | 107 | 2 | 28 | 55 | 4 |
| Asthenia | 88 | 2 | 12 | 33 | 3 |
| Pyrexia | 87 | 2 | 21 | 47 | 9 |
| Nausea | 84 | 2 | 12 | 35 | 1 |
| Product dose omission issue | 77 | 1 | 1 | 32 | 0 |
| Atrial fibrillation | 77 | 2 | 16 | 30 | 5 |
| Malignant neoplasm progression | 71 | 2 | 41 | 31 | 7 |
| Neutrophil count decreased | 69 | 1 | 8 | 19 | 9 |
| Dyspnoea | 69 | 2 | 5 | 30 | 1 |
| Neutropenia | 68 | 2 | 18 | 21 | 6 |
| White blood cell count increased | 66 | 2 | 7 | 16 | 2 |
| Dizziness | 66 | 1 | 6 | 13 | 0 |
| Arthralgia | 66 | 2 | 3 | 9 | 0 |
| Thrombocytopenia | 62 | 1 | 9 | 7 | 4 |
| Pancytopenia | 61 | 2 | 4 | 8 | 0 |
| Peripheral swelling | 60 | 2 | 1 | 15 | 1 |
| Lymphadenopathy | 60 | 2 | 3 | 5 | 0 |