Cytochrome P450 2C19 Inhibitors [MoA]: Side Effects & Safety Data for 20 Drugs
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Cytochrome P450 2C19 Inhibitors [MoA] includes 20 drugs with a combined 267,171 adverse event reports in the FDA FAERS database. Compare their safety profiles, side effects, and outcomes below.
20
Drugs in Class
267,171
Combined Reports
All Cytochrome P450 2C19 Inhibitors [MoA] Drugs Ranked by Reports
| Drug | Brand Name | Reports | Deaths | Hosp. | Death Rate |
|---|---|---|---|---|---|
| OMEPRAZOLE | omeprazole sodium bicarbonate | 87,111 | 8,515 | 19,847 | 9.8% |
| ESOMEPRAZOLE | Esomeprazole Magnesium | 75,631 | 7,030 | 15,221 | 9.3% |
| TOPIRAMATE | Topiramate | 28,609 | 3,527 | 7,098 | 12.3% |
| CANNABIDIOL | Epidiolex | 18,243 | 1,563 | 5,149 | 8.6% |
| FLUCONAZOLE | Fluconazole | 15,157 | 2,546 | 5,821 | 16.8% |
| VORICONAZOLE | Voriconazole | 14,384 | 3,940 | 5,118 | 27.4% |
| EFAVIRENZ | Efavirenz, Emtricitabine and Tenofovir Disoproxil Fumarate | 7,893 | 962 | 1,528 | 12.2% |
| CENOBAMATE | Xcopri | 5,643 | 125 | 1,012 | 2.2% |
| ELAGOLIX | Orilissa | 3,582 | 5 | 299 | 0.1% |
| ESLICARBAZEPINE | Eslicarbazepine Acetate | 3,127 | 97 | 750 | 3.1% |
| NICARDIPINE | NICARDIPINE HYDROCHLORIDE | 2,317 | 182 | 1,073 | 7.9% |
| ETRAVIRINE | Intelence | 1,969 | 257 | 405 | 13.1% |
| OSILODROSTAT | Isturisa | 1,626 | 191 | 526 | 11.7% |
| ORITAVANCIN | Orbactiv | 884 | 29 | 157 | 3.3% |
| PIRTOBRUTINIB | JAYPIRCA | 437 | 130 | 144 | 29.7% |
| ORITAVANCIN DIPHOSPHATE | Kimyrsa | 276 | 4 | 27 | 1.4% |
| TECOVIRIMAT | TPOXX | 137 | 27 | 43 | 19.7% |
| LONAFARNIB | Zokinvy | 59 | 6 | 14 | 10.2% |
| LULICONAZOLE | LULICONAZOLE | 44 | 0 | 3 | N/A |
| TRICLABENDAZOLE | EGATEN | 42 | 0 | 4 | N/A |
Common Side Effects in Cytochrome P450 2C19 Inhibitors [MoA] Drugs
| Side Effect | Reports | Deaths |
|---|---|---|
| Chronic kidney disease | 71,147 | 7,501 |
| Acute kidney injury | 39,190 | 5,319 |
| Renal failure | 29,952 | 5,231 |
| Drug ineffective | 21,779 | 3,314 |
| End stage renal disease | 20,600 | 4,404 |
| Renal injury | 18,962 | 1,694 |
| Off label use | 15,824 | 2,289 |
| Seizure | 9,930 | 248 |
| Gastrooesophageal reflux disease | 9,698 | 857 |
| Pain | 9,261 | 864 |