Cytochrome P450 2C19 Inhibitors [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Chronic kidney disease | 71,147 | 7 | 7,501 | 6,614 | 179 |
| Acute kidney injury | 39,190 | 13 | 5,319 | 7,681 | 756 |
| Renal failure | 29,952 | 11 | 5,231 | 5,542 | 277 |
| Drug ineffective | 21,779 | 16 | 3,314 | 5,655 | 1,645 |
| End stage renal disease | 20,600 | 3 | 4,404 | 2,821 | 86 |
| Renal injury | 18,962 | 5 | 1,694 | 2,218 | 36 |
| Off label use | 15,824 | 17 | 2,289 | 5,426 | 1,574 |
| Seizure | 9,930 | 14 | 248 | 3,132 | 292 |
| Gastrooesophageal reflux disease | 9,698 | 10 | 857 | 2,064 | 631 |
| Pain | 9,261 | 16 | 864 | 2,611 | 1,006 |
| Nausea | 9,250 | 17 | 994 | 3,095 | 1,024 |
| Tubulointerstitial nephritis | 8,886 | 6 | 1,085 | 1,763 | 175 |
| Diarrhoea | 8,517 | 17 | 1,073 | 3,067 | 931 |
| Death | 8,309 | 14 | 8,282 | 931 | 107 |
| Headache | 8,207 | 16 | 872 | 2,489 | 852 |
| Fatigue | 7,869 | 15 | 894 | 2,325 | 979 |
| Drug interaction | 6,860 | 13 | 669 | 3,045 | 774 |
| Product use in unapproved indication | 6,820 | 14 | 957 | 1,932 | 753 |
| Vomiting | 6,737 | 17 | 1,053 | 2,994 | 1,083 |
| Dizziness | 6,296 | 16 | 712 | 1,876 | 692 |
| Dyspnoea | 6,228 | 16 | 985 | 2,827 | 891 |
| Condition aggravated | 5,780 | 15 | 1,216 | 2,132 | 860 |
| Nephrogenic anaemia | 5,742 | 2 | 1,022 | 1,700 | 22 |
| Malaise | 5,710 | 15 | 720 | 2,339 | 848 |
| Product use issue | 5,218 | 12 | 681 | 1,230 | 424 |
| Rash | 5,130 | 16 | 926 | 1,838 | 882 |
| Depression | 4,902 | 13 | 833 | 1,657 | 683 |
| Rebound acid hypersecretion | 4,851 | 2 | 723 | 582 | 19 |
| Fall | 4,759 | 13 | 696 | 2,936 | 749 |
| Intentional product misuse | 4,720 | 10 | 245 | 984 | 224 |