Folate Analog [EPC] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Diarrhoea | 2,896 | 2 | 373 | 1,382 | 169 |
| Neutropenia | 2,537 | 2 | 301 | 736 | 218 |
| Nausea | 2,251 | 2 | 251 | 1,061 | 73 |
| Neuropathy peripheral | 1,735 | 2 | 133 | 252 | 60 |
| Vomiting | 1,608 | 2 | 222 | 942 | 99 |
| Fatigue | 1,566 | 2 | 206 | 667 | 73 |
| Disease progression | 1,543 | 2 | 431 | 212 | 51 |
| Off label use | 1,515 | 2 | 288 | 561 | 167 |
| Pyrexia | 1,323 | 2 | 134 | 1,042 | 83 |
| Thrombocytopenia | 1,286 | 2 | 161 | 363 | 129 |
| Febrile neutropenia | 1,225 | 2 | 189 | 731 | 143 |
| Anaemia | 1,147 | 2 | 169 | 521 | 109 |
| Drug ineffective | 1,070 | 2 | 210 | 294 | 129 |
| Decreased appetite | 998 | 2 | 147 | 496 | 51 |
| Asthenia | 968 | 2 | 134 | 495 | 34 |
| Death | 894 | 2 | 893 | 97 | 29 |
| Abdominal pain | 893 | 2 | 118 | 600 | 51 |
| Hypertension | 795 | 2 | 76 | 254 | 58 |
| Malignant neoplasm progression | 767 | 2 | 217 | 165 | 27 |
| Mucosal inflammation | 730 | 2 | 105 | 317 | 74 |
| Rash | 708 | 2 | 81 | 194 | 44 |
| Stomatitis | 690 | 2 | 95 | 266 | 44 |
| Acute kidney injury | 673 | 2 | 94 | 503 | 99 |
| General physical health deterioration | 665 | 2 | 157 | 549 | 48 |
| Sepsis | 646 | 2 | 280 | 427 | 123 |
| Dyspnoea | 631 | 2 | 89 | 344 | 61 |
| Pulmonary embolism | 625 | 2 | 114 | 373 | 91 |
| Leukopenia | 608 | 2 | 55 | 159 | 45 |
| Neoplasm progression | 601 | 2 | 161 | 100 | 24 |
| Product use in unapproved indication | 582 | 2 | 78 | 142 | 52 |