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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Histamine H1 Receptor Antagonists [MoA]: Side Effects & Safety Data for 13 Drugs

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Histamine H1 Receptor Antagonists [MoA] includes 13 drugs with a combined 133,955 adverse event reports in the FDA FAERS database. Compare their safety profiles, side effects, and outcomes below.

13
Drugs in Class
133,955
Combined Reports

All Histamine H1 Receptor Antagonists [MoA] Drugs Ranked by Reports

Drug Brand Name Reports Deaths Hosp. Death Rate
CETIRIZINE Cetirizine 47,655 4,787 8,423 10.0%
DIPHENHYDRAMINE Allergy Relief 25,827 10,508 6,849 40.7%
FEXOFENADINE Fexofenadine HCl 21,453 80 535 0.4%
LEVOCETIRIZINE allergy relief 10,782 554 884 5.1%
OLOPATADINE PATADAY ONCE DAILY RELIEF 8,787 89 171 1.0%
AZELASTINE Azelastine Hydrochloride 5,896 12 89 0.2%
KETOTIFEN Eye Itch Relief 5,209 9 99 0.2%
DESLORATADINE Desloratadine 3,141 160 1,389 5.1%
DIMENHYDRINATE Driminate 1,934 160 836 8.3%
CHLORPHENIRAMINE ACTIDOM DA 1,919 607 663 31.6%
EPINASTINE EPINASTINE HYDROCHLORIDE 843 6 25 0.7%
ALCAFTADINE Alcaftadine 465 0 4 N/A
CARBINOXAMINE Carbinoxamine Maleate Extended-Release Oral Suspension 44 3 2 6.8%

Common Side Effects in Histamine H1 Receptor Antagonists [MoA] Drugs

Side EffectReportsDeaths
Drug ineffective 31,139 1,809
Treatment failure 14,610 1,443
Fatigue 14,309 2,706
Pain 12,244 2,224
Off label use 11,883 2,384
Rheumatoid arthritis 9,708 2,437
Abdominal discomfort 9,669 2,183
Alopecia 9,276 2,117
Rash 9,084 2,389
Hypersensitivity 8,820 2,243
View detailed side effects for this class → Compare drugs in this class →