Histamine H1 Receptor Antagonists [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Drug ineffective | 31,139 | 12 | 1,809 | 3,831 | 2,238 |
| Treatment failure | 14,610 | 12 | 1,443 | 1,673 | 1,493 |
| Fatigue | 14,309 | 11 | 2,706 | 4,009 | 2,920 |
| Pain | 12,244 | 11 | 2,224 | 3,801 | 2,638 |
| Off label use | 11,883 | 12 | 2,384 | 4,084 | 2,668 |
| Rheumatoid arthritis | 9,708 | 5 | 2,437 | 3,286 | 2,755 |
| Abdominal discomfort | 9,669 | 10 | 2,183 | 3,073 | 2,534 |
| Alopecia | 9,276 | 10 | 2,117 | 2,941 | 2,485 |
| Rash | 9,084 | 10 | 2,389 | 3,130 | 2,486 |
| Hypersensitivity | 8,820 | 12 | 2,243 | 2,765 | 2,253 |
| Systemic lupus erythematosus | 8,794 | 5 | 2,324 | 2,905 | 2,507 |
| Headache | 8,783 | 11 | 2,343 | 3,227 | 2,269 |
| Pemphigus | 8,589 | 5 | 2,122 | 2,586 | 2,385 |
| Somnolence | 8,343 | 11 | 348 | 892 | 195 |
| Pruritus | 8,142 | 12 | 1,560 | 2,344 | 1,556 |
| Glossodynia | 7,949 | 5 | 2,309 | 2,610 | 2,388 |
| Infusion related reaction | 7,812 | 6 | 2,450 | 3,135 | 2,288 |
| Product use issue | 7,747 | 10 | 1,368 | 1,858 | 1,417 |
| Swelling | 7,422 | 10 | 2,148 | 2,822 | 2,366 |
| Nausea | 7,274 | 10 | 1,756 | 3,487 | 2,200 |
| Contraindicated product administered | 6,863 | 10 | 1,590 | 1,999 | 1,660 |
| Hand deformity | 6,812 | 3 | 2,290 | 2,630 | 2,399 |
| Arthralgia | 6,663 | 10 | 2,319 | 3,045 | 2,359 |
| Product use in unapproved indication | 6,633 | 10 | 1,384 | 1,850 | 1,528 |
| Arthropathy | 6,601 | 5 | 1,993 | 2,671 | 2,242 |
| Drug intolerance | 6,480 | 10 | 1,869 | 2,340 | 1,911 |
| Dizziness | 6,460 | 10 | 1,876 | 2,339 | 1,827 |
| Joint swelling | 6,455 | 8 | 2,338 | 2,660 | 2,357 |
| Hepatic enzyme increased | 6,451 | 6 | 2,475 | 2,608 | 2,380 |
| Maternal exposure during pregnancy | 6,422 | 9 | 1,726 | 2,315 | 1,969 |