Does AFATINIB Cause Intestinal perforation? 10 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 10 reports of Intestinal perforation have been filed in association with AFATINIB (Gilotrif). This represents 0.2% of all adverse event reports for AFATINIB.
10
Reports of Intestinal perforation with AFATINIB
0.2%
of all AFATINIB reports
3
Deaths
8
Hospitalizations
How Dangerous Is Intestinal perforation From AFATINIB?
Of the 10 reports, 3 (30.0%) resulted in death, 8 (80.0%) required hospitalization, and 1 (10.0%) were considered life-threatening.
Is Intestinal perforation Listed in the Official Label?
Yes, Intestinal perforation is listed as a known adverse reaction in the official FDA drug label for AFATINIB.
What Other Side Effects Does AFATINIB Cause?
Diarrhoea (2,001)
Malignant neoplasm progression (1,622)
Rash (808)
Stomatitis (468)
Death (443)
Nausea (430)
Decreased appetite (412)
Vomiting (381)
Paronychia (344)
Dehydration (323)
What Other Drugs Cause Intestinal perforation?
ADALIMUMAB (1,010)
BEVACIZUMAB (600)
RITUXIMAB (321)
TOCILIZUMAB (276)
PREDNISONE (266)
CYCLOPHOSPHAMIDE (262)
DOXORUBICIN (240)
LENVATINIB (228)
INFLIXIMAB (226)
PEMBROLIZUMAB (220)
Which AFATINIB Alternatives Have Lower Intestinal perforation Risk?
AFATINIB vs AFINITOR
AFATINIB vs AFLIBERCEPT
AFATINIB vs AGALSIDASE ALFA
AFATINIB vs AGALSIDASE BETA
AFATINIB vs AGOMELATINE