Does FLUOROURACIL Cause Neurotoxicity? 735 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 735 reports of Neurotoxicity have been filed in association with FLUOROURACIL (FLUOROURACIL). This represents 1.4% of all adverse event reports for FLUOROURACIL.
735
Reports of Neurotoxicity with FLUOROURACIL
1.4%
of all FLUOROURACIL reports
33
Deaths
101
Hospitalizations
How Dangerous Is Neurotoxicity From FLUOROURACIL?
Of the 735 reports, 33 (4.5%) resulted in death, 101 (13.7%) required hospitalization, and 19 (2.6%) were considered life-threatening.
Is Neurotoxicity Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for FLUOROURACIL. However, 735 reports have been filed with the FAERS database.
What Other Side Effects Does FLUOROURACIL Cause?
Diarrhoea (5,373)
Neutropenia (4,400)
Nausea (3,757)
Vomiting (2,836)
Off label use (2,788)
Neuropathy peripheral (2,605)
Thrombocytopenia (2,426)
Fatigue (2,421)
Disease progression (2,377)
Febrile neutropenia (2,230)
What Other Drugs Cause Neurotoxicity?
AXICABTAGENE CILOLEUCEL (1,327)
OXALIPLATIN (1,272)
METHOTREXATE (1,083)
CYCLOPHOSPHAMIDE (763)
PACLITAXEL (734)
TACROLIMUS (623)
BEVACIZUMAB (588)
VINCRISTINE (555)
CAPECITABINE (553)
BLINATUMOMAB (530)
Which FLUOROURACIL Alternatives Have Lower Neurotoxicity Risk?
FLUOROURACIL vs FLUOROURACIL\IRINOTECAN\LEUCOVORIN
FLUOROURACIL vs FLUOROURACIL\IRINOTECAN\LEUCOVORIN\OXALIPLATIN
FLUOROURACIL vs FLUOROURACIL\LEUCOVORIN\OXALIPLATIN
FLUOROURACIL vs FLUOXETINE
FLUOROURACIL vs FLUOXETINE\FLUOXETINE