Does METHOTREXATE Cause Neurotoxicity? 1,083 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 1,083 reports of Neurotoxicity have been filed in association with METHOTREXATE (Methotrexate). This represents 0.4% of all adverse event reports for METHOTREXATE.
1,083
Reports of Neurotoxicity with METHOTREXATE
0.4%
of all METHOTREXATE reports
131
Deaths
352
Hospitalizations
How Dangerous Is Neurotoxicity From METHOTREXATE?
Of the 1,083 reports, 131 (12.1%) resulted in death, 352 (32.5%) required hospitalization, and 106 (9.8%) were considered life-threatening.
Is Neurotoxicity Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 1,083 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Neurotoxicity?
AXICABTAGENE CILOLEUCEL (1,327)
OXALIPLATIN (1,272)
CYCLOPHOSPHAMIDE (763)
FLUOROURACIL (735)
PACLITAXEL (734)
TACROLIMUS (623)
BEVACIZUMAB (588)
VINCRISTINE (555)
CAPECITABINE (553)
BLINATUMOMAB (530)
Which METHOTREXATE Alternatives Have Lower Neurotoxicity Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA