Neurotoxicity: Which Medications Cause It? (13,539 Reports Across 447 Drugs)
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Neurotoxicity has been reported as an adverse event with 447 different drugs in the FDA's FAERS database, with 13,539 total reports. 1,329 of these reports resulted in death.The drugs most commonly associated with Neurotoxicity are AXICABTAGENE CILOLEUCEL, OXALIPLATIN, and METHOTREXATE.
13,539
Total Reports
447
Drugs Involved
1,329
Deaths
4,828
Hospitalizations
52.1 yrs
Average Patient Age
46.8% / 53.2%
Female / Male
Which Drugs Cause Neurotoxicity Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| AXICABTAGENE CILOLEUCEL | 1,327 | 15.4% | 239 | 615 | 98 |
| OXALIPLATIN | 1,272 | 2.3% | 50 | 148 | 52 |
| METHOTREXATE | 1,083 | 0.4% | 131 | 352 | 106 |
| CYCLOPHOSPHAMIDE | 763 | 0.6% | 135 | 233 | 57 |
| FLUOROURACIL | 735 | 1.4% | 33 | 101 | 19 |
| PACLITAXEL | 734 | 1.0% | 43 | 100 | 22 |
| TACROLIMUS | 623 | 0.7% | 45 | 244 | 40 |
| BEVACIZUMAB | 588 | 0.8% | 60 | 56 | 16 |
| VINCRISTINE | 555 | 0.8% | 89 | 124 | 36 |
| CAPECITABINE | 553 | 0.9% | 28 | 70 | 31 |
| BLINATUMOMAB | 530 | 5.8% | 69 | 148 | 54 |
| LEUCOVORIN | 504 | 2.0% | 37 | 56 | 15 |
| METRONIDAZOLE | 465 | 2.1% | 3 | 219 | 15 |
| ACYCLOVIR | 460 | 3.2% | 23 | 282 | 37 |
| DOXORUBICIN | 447 | 0.5% | 67 | 95 | 33 |
| DEXAMETHASONE | 431 | 0.3% | 60 | 115 | 32 |
| CYTARABINE | 417 | 0.9% | 68 | 110 | 49 |
| TISAGENLECLEUCEL | 411 | 9.7% | 146 | 155 | 100 |
| VALACYCLOVIR | 404 | 3.1% | 7 | 334 | 42 |
| PREDNISONE | 374 | 0.2% | 47 | 118 | 25 |