Does IBRUTINIB Cause Leukoencephalopathy? 8 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 8 reports of Leukoencephalopathy have been filed in association with IBRUTINIB (Imbruvica). This represents 0.0% of all adverse event reports for IBRUTINIB.
8
Reports of Leukoencephalopathy with IBRUTINIB
0.0%
of all IBRUTINIB reports
5
Deaths
3
Hospitalizations
How Dangerous Is Leukoencephalopathy From IBRUTINIB?
Of the 8 reports, 5 (62.5%) resulted in death, 3 (37.5%) required hospitalization, and 1 (12.5%) were considered life-threatening.
Is Leukoencephalopathy Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for IBRUTINIB. However, 8 reports have been filed with the FAERS database.
What Other Side Effects Does IBRUTINIB Cause?
Death (8,007)
Off label use (5,446)
Fatigue (4,479)
Diarrhoea (3,903)
Atrial fibrillation (3,671)
Pneumonia (3,015)
Incorrect dose administered (2,752)
Contusion (2,712)
Fall (2,375)
Asthenia (2,200)
What Other Drugs Cause Leukoencephalopathy?
METHOTREXATE (717)
CYTARABINE (208)
VINCRISTINE (138)
CYCLOPHOSPHAMIDE (137)
RITUXIMAB (118)
DEXAMETHASONE (107)
FLUOROURACIL (103)
FLUDARABINE (89)
TACROLIMUS (79)
CAPECITABINE (77)
Which IBRUTINIB Alternatives Have Lower Leukoencephalopathy Risk?
IBRUTINIB vs IBUPROFEN
IBRUTINIB vs IBUPROFEN LYSINE
IBRUTINIB vs IBUPROFEN UNKNOWN PRODUCT
IBRUTINIB vs IBUPROFEN\IBUPROFEN
IBRUTINIB vs IBUPROFEN\PHENYLEPHRINE