Does FLUOROURACIL Cause Leukoencephalopathy? 103 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 103 reports of Leukoencephalopathy have been filed in association with FLUOROURACIL (FLUOROURACIL). This represents 0.2% of all adverse event reports for FLUOROURACIL.
103
Reports of Leukoencephalopathy with FLUOROURACIL
0.2%
of all FLUOROURACIL reports
12
Deaths
41
Hospitalizations
How Dangerous Is Leukoencephalopathy From FLUOROURACIL?
Of the 103 reports, 12 (11.7%) resulted in death, 41 (39.8%) required hospitalization, and 7 (6.8%) were considered life-threatening.
Is Leukoencephalopathy Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for FLUOROURACIL. However, 103 reports have been filed with the FAERS database.
What Other Side Effects Does FLUOROURACIL Cause?
Diarrhoea (5,373)
Neutropenia (4,400)
Nausea (3,757)
Vomiting (2,836)
Off label use (2,788)
Neuropathy peripheral (2,605)
Thrombocytopenia (2,426)
Fatigue (2,421)
Disease progression (2,377)
Febrile neutropenia (2,230)
What Other Drugs Cause Leukoencephalopathy?
METHOTREXATE (717)
CYTARABINE (208)
VINCRISTINE (138)
CYCLOPHOSPHAMIDE (137)
RITUXIMAB (118)
DEXAMETHASONE (107)
FLUDARABINE (89)
TACROLIMUS (79)
CAPECITABINE (77)
METHADONE (76)
Which FLUOROURACIL Alternatives Have Lower Leukoencephalopathy Risk?
FLUOROURACIL vs FLUOROURACIL\IRINOTECAN\LEUCOVORIN
FLUOROURACIL vs FLUOROURACIL\IRINOTECAN\LEUCOVORIN\OXALIPLATIN
FLUOROURACIL vs FLUOROURACIL\LEUCOVORIN\OXALIPLATIN
FLUOROURACIL vs FLUOXETINE
FLUOROURACIL vs FLUOXETINE\FLUOXETINE