Does METHOTREXATE Cause Leukoencephalopathy? 717 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 717 reports of Leukoencephalopathy have been filed in association with METHOTREXATE (Methotrexate). This represents 0.3% of all adverse event reports for METHOTREXATE.
717
Reports of Leukoencephalopathy with METHOTREXATE
0.3%
of all METHOTREXATE reports
150
Deaths
309
Hospitalizations
How Dangerous Is Leukoencephalopathy From METHOTREXATE?
Of the 717 reports, 150 (20.9%) resulted in death, 309 (43.1%) required hospitalization, and 80 (11.2%) were considered life-threatening.
Is Leukoencephalopathy Listed in the Official Label?
Yes, Leukoencephalopathy is listed as a known adverse reaction in the official FDA drug label for METHOTREXATE.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Leukoencephalopathy?
CYTARABINE (208)
VINCRISTINE (138)
CYCLOPHOSPHAMIDE (137)
RITUXIMAB (118)
DEXAMETHASONE (107)
FLUOROURACIL (103)
FLUDARABINE (89)
TACROLIMUS (79)
CAPECITABINE (77)
METHADONE (76)
Which METHOTREXATE Alternatives Have Lower Leukoencephalopathy Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA