Leukoencephalopathy: Which Medications Cause It? (2,324 Reports Across 162 Drugs)
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Leukoencephalopathy has been reported as an adverse event with 162 different drugs in the FDA's FAERS database, with 2,324 total reports. 413 of these reports resulted in death.The drugs most commonly associated with Leukoencephalopathy are METHOTREXATE, CYTARABINE, and VINCRISTINE.
2,324
Total Reports
162
Drugs Involved
413
Deaths
1,134
Hospitalizations
44.1 yrs
Average Patient Age
49.2% / 50.8%
Female / Male
Which Drugs Cause Leukoencephalopathy Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| METHOTREXATE | 717 | 0.3% | 150 | 309 | 80 |
| CYTARABINE | 208 | 0.5% | 47 | 88 | 16 |
| VINCRISTINE | 138 | 0.2% | 21 | 79 | 7 |
| CYCLOPHOSPHAMIDE | 137 | 0.1% | 36 | 66 | 3 |
| RITUXIMAB | 118 | 0.1% | 29 | 45 | 2 |
| DEXAMETHASONE | 107 | 0.1% | 12 | 44 | 13 |
| FLUOROURACIL | 103 | 0.2% | 12 | 41 | 7 |
| FLUDARABINE | 89 | 0.4% | 53 | 30 | 11 |
| TACROLIMUS | 79 | 0.1% | 10 | 44 | 7 |
| CAPECITABINE | 77 | 0.1% | 16 | 49 | 8 |
| METHADONE | 76 | 0.3% | 5 | 63 | 11 |
| OXYCODONE | 70 | 0.0% | 11 | 58 | 22 |
| PREDNISOLONE | 70 | 0.1% | 15 | 18 | 3 |
| OXALIPLATIN | 66 | 0.1% | 18 | 37 | 5 |
| BEVACIZUMAB | 63 | 0.1% | 8 | 20 | 3 |
| PREDNISONE | 63 | 0.0% | 14 | 35 | 4 |
| FENTANYL | 62 | 0.1% | 4 | 56 | 12 |
| PEGASPARGASE | 61 | 0.5% | 7 | 49 | 6 |
| CYCLOSPORINE | 59 | 0.1% | 13 | 24 | 6 |
| DOXORUBICIN | 55 | 0.1% | 15 | 25 | 1 |