Does METHADONE Cause Leukoencephalopathy? 76 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 76 reports of Leukoencephalopathy have been filed in association with METHADONE (METHADONE HYDROCHLORIDE). This represents 0.3% of all adverse event reports for METHADONE.
76
Reports of Leukoencephalopathy with METHADONE
0.3%
of all METHADONE reports
5
Deaths
63
Hospitalizations
How Dangerous Is Leukoencephalopathy From METHADONE?
Of the 76 reports, 5 (6.6%) resulted in death, 63 (82.9%) required hospitalization, and 11 (14.5%) were considered life-threatening.
Is Leukoencephalopathy Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHADONE. However, 76 reports have been filed with the FAERS database.
What Other Side Effects Does METHADONE Cause?
Drug dependence (5,739)
Toxicity to various agents (4,586)
Drug abuse (4,480)
Overdose (3,472)
Pain (2,754)
Death (2,716)
Emotional distress (2,388)
Drug withdrawal syndrome (2,127)
Foetal exposure during pregnancy (1,759)
Drug withdrawal syndrome neonatal (1,458)
What Other Drugs Cause Leukoencephalopathy?
METHOTREXATE (717)
CYTARABINE (208)
VINCRISTINE (138)
CYCLOPHOSPHAMIDE (137)
RITUXIMAB (118)
DEXAMETHASONE (107)
FLUOROURACIL (103)
FLUDARABINE (89)
TACROLIMUS (79)
CAPECITABINE (77)
Which METHADONE Alternatives Have Lower Leukoencephalopathy Risk?
METHADONE vs METHAMPHETAMINE
METHADONE vs METHENAMINE HIPPURATE
METHADONE vs METHIMAZOLE
METHADONE vs METHOCARBAMOL
METHADONE vs METHOHEXITAL