Does LACTULOSE Cause Hyperammonaemia? 13 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 13 reports of Hyperammonaemia have been filed in association with LACTULOSE (LACTULOSE). This represents 0.3% of all adverse event reports for LACTULOSE.
13
Reports of Hyperammonaemia with LACTULOSE
0.3%
of all LACTULOSE reports
5
Deaths
9
Hospitalizations
How Dangerous Is Hyperammonaemia From LACTULOSE?
Of the 13 reports, 5 (38.5%) resulted in death, 9 (69.2%) required hospitalization, and 3 (23.1%) were considered life-threatening.
Is Hyperammonaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for LACTULOSE. However, 13 reports have been filed with the FAERS database.
What Other Side Effects Does LACTULOSE Cause?
Fall (833)
Constipation (818)
Hypotension (654)
Cognitive disorder (649)
Balance disorder (641)
Orthostatic hypotension (589)
Pain (587)
Sedation (581)
Toxicity to various agents (558)
Depressed level of consciousness (552)
What Other Drugs Cause Hyperammonaemia?
VALPROIC ACID (581)
VALPROATE (328)
FLUOROURACIL (263)
DIVALPROEX (256)
LEVETIRACETAM (192)
TACROLIMUS (181)
ACETAMINOPHEN (177)
OXALIPLATIN (160)
TOPIRAMATE (156)
GLYCEROL PHENYLBUTYRATE (147)
Which LACTULOSE Alternatives Have Lower Hyperammonaemia Risk?
LACTULOSE vs LAMICTAL
LACTULOSE vs LAMIVUDINE
LACTULOSE vs LAMIVUDINE\NEVIRAPINE\ZIDOVUDINE
LACTULOSE vs LAMIVUDINE\TENOFOVIR
LACTULOSE vs LAMIVUDINE\TENOFOVIR DISOPROXIL