Does LEFLUNOMIDE Cause Hyperammonaemia? 22 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 22 reports of Hyperammonaemia have been filed in association with LEFLUNOMIDE (Leflunomide). This represents 0.0% of all adverse event reports for LEFLUNOMIDE.
22
Reports of Hyperammonaemia with LEFLUNOMIDE
0.0%
of all LEFLUNOMIDE reports
19
Deaths
17
Hospitalizations
How Dangerous Is Hyperammonaemia From LEFLUNOMIDE?
Of the 22 reports, 19 (86.4%) resulted in death, 17 (77.3%) required hospitalization, and 14 (63.6%) were considered life-threatening.
Is Hyperammonaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for LEFLUNOMIDE. However, 22 reports have been filed with the FAERS database.
What Other Side Effects Does LEFLUNOMIDE Cause?
Drug ineffective (31,396)
Rheumatoid arthritis (20,886)
Pain (15,594)
Drug intolerance (14,142)
Joint swelling (13,026)
Fatigue (11,959)
Arthralgia (11,880)
Rash (11,239)
Contraindicated product administered (11,206)
Abdominal discomfort (10,333)
What Other Drugs Cause Hyperammonaemia?
VALPROIC ACID (581)
VALPROATE (328)
FLUOROURACIL (263)
DIVALPROEX (256)
LEVETIRACETAM (192)
TACROLIMUS (181)
ACETAMINOPHEN (177)
OXALIPLATIN (160)
TOPIRAMATE (156)
GLYCEROL PHENYLBUTYRATE (147)
Which LEFLUNOMIDE Alternatives Have Lower Hyperammonaemia Risk?
LEFLUNOMIDE vs LEMBOREXANT
LEFLUNOMIDE vs LENACAPAVIR
LEFLUNOMIDE vs LENALIDOMIDE
LEFLUNOMIDE vs LENIOLISIB
LEFLUNOMIDE vs LENOGRASTIM