Does LEUCOVORIN Cause Hyperammonaemia? 86 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 86 reports of Hyperammonaemia have been filed in association with LEUCOVORIN (LEUCOVORIN CALCIUM). This represents 0.3% of all adverse event reports for LEUCOVORIN.
86
Reports of Hyperammonaemia with LEUCOVORIN
0.3%
of all LEUCOVORIN reports
5
Deaths
45
Hospitalizations
How Dangerous Is Hyperammonaemia From LEUCOVORIN?
Of the 86 reports, 5 (5.8%) resulted in death, 45 (52.3%) required hospitalization, and 15 (17.4%) were considered life-threatening.
Is Hyperammonaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for LEUCOVORIN. However, 86 reports have been filed with the FAERS database.
What Other Side Effects Does LEUCOVORIN Cause?
Diarrhoea (2,594)
Neutropenia (2,291)
Nausea (1,977)
Neuropathy peripheral (1,557)
Disease progression (1,456)
Fatigue (1,443)
Vomiting (1,441)
Off label use (1,390)
Thrombocytopenia (1,181)
Pyrexia (1,148)
What Other Drugs Cause Hyperammonaemia?
VALPROIC ACID (581)
VALPROATE (328)
FLUOROURACIL (263)
DIVALPROEX (256)
LEVETIRACETAM (192)
TACROLIMUS (181)
ACETAMINOPHEN (177)
OXALIPLATIN (160)
TOPIRAMATE (156)
GLYCEROL PHENYLBUTYRATE (147)
Which LEUCOVORIN Alternatives Have Lower Hyperammonaemia Risk?
LEUCOVORIN vs LEUCOVORIN\LEUCOVORIN
LEUCOVORIN vs LEUPROLIDE
LEUCOVORIN vs LEVALBUTEROL
LEUCOVORIN vs LEVAMISOLE
LEUCOVORIN vs LEVAQUIN