Does MELPHALAN Cause Agranulocytosis? 60 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 60 reports of Agranulocytosis have been filed in association with MELPHALAN (Melphalan Hydrochloride). This represents 0.4% of all adverse event reports for MELPHALAN.
60
Reports of Agranulocytosis with MELPHALAN
0.4%
of all MELPHALAN reports
5
Deaths
27
Hospitalizations
How Dangerous Is Agranulocytosis From MELPHALAN?
Of the 60 reports, 5 (8.3%) resulted in death, 27 (45.0%) required hospitalization, and 9 (15.0%) were considered life-threatening.
Is Agranulocytosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for MELPHALAN. However, 60 reports have been filed with the FAERS database.
What Other Side Effects Does MELPHALAN Cause?
Off label use (2,002)
Febrile neutropenia (931)
Drug ineffective (853)
Neutropenia (810)
Mucosal inflammation (804)
Plasma cell myeloma (781)
Product use in unapproved indication (765)
Thrombocytopenia (701)
Diarrhoea (698)
Pyrexia (667)
What Other Drugs Cause Agranulocytosis?
CLOZAPINE (1,766)
CYCLOPHOSPHAMIDE (1,242)
RITUXIMAB (1,154)
SULFAMETHOXAZOLE\TRIMETHOPRIM (797)
PANTOPRAZOLE (599)
METHOTREXATE (550)
SODIUM (549)
EPIRUBICIN (491)
METAMIZOLE (438)
DOCETAXEL (436)
Which MELPHALAN Alternatives Have Lower Agranulocytosis Risk?
MELPHALAN vs MEMANTINE
MELPHALAN vs MENINGOCOCCAL GROUP B VACCINE
MELPHALAN vs MENINGOCOCCAL POLYSACCHARIDE VACCINE A\NEISSERIA MENINGITIDIS GROUP A CAPSULAR POLYSACCHARIDE ANTIGEN
MELPHALAN vs MENOTROPINS
MELPHALAN vs MENTHOL