Does MELPHALAN Cause Cardiotoxicity? 50 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 50 reports of Cardiotoxicity have been filed in association with MELPHALAN (Melphalan Hydrochloride). This represents 0.3% of all adverse event reports for MELPHALAN.
50
Reports of Cardiotoxicity with MELPHALAN
0.3%
of all MELPHALAN reports
18
Deaths
3
Hospitalizations
How Dangerous Is Cardiotoxicity From MELPHALAN?
Of the 50 reports, 18 (36.0%) resulted in death, 3 (6.0%) required hospitalization, and 3 (6.0%) were considered life-threatening.
Is Cardiotoxicity Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for MELPHALAN. However, 50 reports have been filed with the FAERS database.
What Other Side Effects Does MELPHALAN Cause?
Off label use (2,002)
Febrile neutropenia (931)
Drug ineffective (853)
Neutropenia (810)
Mucosal inflammation (804)
Plasma cell myeloma (781)
Product use in unapproved indication (765)
Thrombocytopenia (701)
Diarrhoea (698)
Pyrexia (667)
What Other Drugs Cause Cardiotoxicity?
DOXORUBICIN (1,366)
CYCLOPHOSPHAMIDE (1,009)
TRASTUZUMAB (950)
VINCRISTINE (446)
FLUOROURACIL (425)
RITUXIMAB (389)
ETOPOSIDE (366)
CAPECITABINE (307)
TOCILIZUMAB (278)
PREDNISONE (277)
Which MELPHALAN Alternatives Have Lower Cardiotoxicity Risk?
MELPHALAN vs MEMANTINE
MELPHALAN vs MENINGOCOCCAL GROUP B VACCINE
MELPHALAN vs MENINGOCOCCAL POLYSACCHARIDE VACCINE A\NEISSERIA MENINGITIDIS GROUP A CAPSULAR POLYSACCHARIDE ANTIGEN
MELPHALAN vs MENOTROPINS
MELPHALAN vs MENTHOL