Does MERCAPTOPURINE Cause Hyperammonaemia? 19 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 19 reports of Hyperammonaemia have been filed in association with MERCAPTOPURINE (Mercaptopurine). This represents 0.2% of all adverse event reports for MERCAPTOPURINE.
19
Reports of Hyperammonaemia with MERCAPTOPURINE
0.2%
of all MERCAPTOPURINE reports
8
Deaths
17
Hospitalizations
How Dangerous Is Hyperammonaemia From MERCAPTOPURINE?
Of the 19 reports, 8 (42.1%) resulted in death, 17 (89.5%) required hospitalization, and 6 (31.6%) were considered life-threatening.
Is Hyperammonaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for MERCAPTOPURINE. However, 19 reports have been filed with the FAERS database.
What Other Side Effects Does MERCAPTOPURINE Cause?
Febrile neutropenia (1,853)
Off label use (893)
Pyrexia (855)
Drug ineffective (721)
Vomiting (488)
Neutropenia (485)
Nausea (418)
Pneumonia (394)
Pancytopenia (392)
Sepsis (389)
What Other Drugs Cause Hyperammonaemia?
VALPROIC ACID (581)
VALPROATE (328)
FLUOROURACIL (263)
DIVALPROEX (256)
LEVETIRACETAM (192)
TACROLIMUS (181)
ACETAMINOPHEN (177)
OXALIPLATIN (160)
TOPIRAMATE (156)
GLYCEROL PHENYLBUTYRATE (147)
Which MERCAPTOPURINE Alternatives Have Lower Hyperammonaemia Risk?
MERCAPTOPURINE vs MEROPENEM
MERCAPTOPURINE vs MEROPENEM ANHYDROUS
MERCAPTOPURINE vs MESALAMINE
MERCAPTOPURINE vs MESNA
MERCAPTOPURINE vs METAMIZOLE