Does METHOTREXATE Cause Appendicitis? 193 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 193 reports of Appendicitis have been filed in association with METHOTREXATE (Methotrexate). This represents 0.1% of all adverse event reports for METHOTREXATE.
193
Reports of Appendicitis with METHOTREXATE
0.1%
of all METHOTREXATE reports
5
Deaths
119
Hospitalizations
How Dangerous Is Appendicitis From METHOTREXATE?
Of the 193 reports, 5 (2.6%) resulted in death, 119 (61.7%) required hospitalization, and 11 (5.7%) were considered life-threatening.
Is Appendicitis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 193 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Appendicitis?
ADALIMUMAB (372)
METRONIDAZOLE (291)
GABAPENTIN (281)
ONDANSETRON (278)
SIMVASTATIN (270)
CEFTRIAXONE (268)
HYDROMORPHONE (265)
ALBUTEROL (264)
ALLOPURINOL (264)
LANSOPRAZOLE (263)
Which METHOTREXATE Alternatives Have Lower Appendicitis Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA