Does METHOTREXATE Cause Intervertebral disc protrusion? 648 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 648 reports of Intervertebral disc protrusion have been filed in association with METHOTREXATE (Methotrexate). This represents 0.3% of all adverse event reports for METHOTREXATE.
648
Reports of Intervertebral disc protrusion with METHOTREXATE
0.3%
of all METHOTREXATE reports
12
Deaths
338
Hospitalizations
How Dangerous Is Intervertebral disc protrusion From METHOTREXATE?
Of the 648 reports, 12 (1.9%) resulted in death, 338 (52.2%) required hospitalization, and 17 (2.6%) were considered life-threatening.
Is Intervertebral disc protrusion Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 648 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Intervertebral disc protrusion?
ADALIMUMAB (2,760)
ETANERCEPT (751)
SODIUM OXYBATE (427)
PREGABALIN (415)
TOFACITINIB (393)
UPADACITINIB (384)
INTERFERON BETA-1A (295)
PREDNISONE (285)
SECUKINUMAB (268)
ABATACEPT (257)
Which METHOTREXATE Alternatives Have Lower Intervertebral disc protrusion Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA