Does METHOTREXATE Cause Joint stiffness? 2,304 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 2,304 reports of Joint stiffness have been filed in association with METHOTREXATE (Methotrexate). This represents 0.9% of all adverse event reports for METHOTREXATE.
2,304
Reports of Joint stiffness with METHOTREXATE
0.9%
of all METHOTREXATE reports
429
Deaths
504
Hospitalizations
How Dangerous Is Joint stiffness From METHOTREXATE?
Of the 2,304 reports, 429 (18.6%) resulted in death, 504 (21.9%) required hospitalization, and 316 (13.7%) were considered life-threatening.
Is Joint stiffness Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 2,304 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Joint stiffness?
ADALIMUMAB (3,927)
ETANERCEPT (2,944)
TOFACITINIB (1,819)
TOCILIZUMAB (1,749)
ABATACEPT (1,385)
RITUXIMAB (1,366)
LEFLUNOMIDE (1,228)
HYDROXYCHLOROQUINE (1,206)
SULFASALAZINE (1,167)
SECUKINUMAB (1,138)
Which METHOTREXATE Alternatives Have Lower Joint stiffness Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA