Does METHOTREXATE Cause Toxic epidermal necrolysis? 319 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 319 reports of Toxic epidermal necrolysis have been filed in association with METHOTREXATE (Methotrexate). This represents 0.1% of all adverse event reports for METHOTREXATE.
319
Reports of Toxic epidermal necrolysis with METHOTREXATE
0.1%
of all METHOTREXATE reports
181
Deaths
159
Hospitalizations
How Dangerous Is Toxic epidermal necrolysis From METHOTREXATE?
Of the 319 reports, 181 (56.7%) resulted in death, 159 (49.8%) required hospitalization, and 88 (27.6%) were considered life-threatening.
Is Toxic epidermal necrolysis Listed in the Official Label?
Yes, Toxic epidermal necrolysis is listed as a known adverse reaction in the official FDA drug label for METHOTREXATE.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Toxic epidermal necrolysis?
ACETAMINOPHEN (980)
LAMOTRIGINE (941)
ALLOPURINOL (858)
IBUPROFEN (764)
SULFAMETHOXAZOLE\TRIMETHOPRIM (592)
CIPROFLOXACIN (576)
FUROSEMIDE (521)
VANCOMYCIN (515)
PIPERACILLIN\TAZOBACTAM (490)
PEMBROLIZUMAB (444)
Which METHOTREXATE Alternatives Have Lower Toxic epidermal necrolysis Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA