Toxic epidermal necrolysis: Which Medications Cause It? (9,797 Reports Across 710 Drugs)
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Toxic epidermal necrolysis has been reported as an adverse event with 710 different drugs in the FDA's FAERS database, with 9,797 total reports. 3,217 of these reports resulted in death.The drugs most commonly associated with Toxic epidermal necrolysis are ACETAMINOPHEN, LAMOTRIGINE, and ALLOPURINOL.
9,797
Total Reports
710
Drugs Involved
3,217
Deaths
6,255
Hospitalizations
51.7 yrs
Average Patient Age
55.2% / 44.8%
Female / Male
Which Drugs Cause Toxic epidermal necrolysis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| ACETAMINOPHEN | 980 | 0.7% | 261 | 677 | 289 |
| LAMOTRIGINE | 941 | 2.0% | 169 | 680 | 311 |
| ALLOPURINOL | 858 | 4.5% | 407 | 522 | 251 |
| IBUPROFEN | 764 | 0.9% | 72 | 598 | 216 |
| SULFAMETHOXAZOLE\TRIMETHOPRIM | 592 | 1.5% | 217 | 380 | 187 |
| CIPROFLOXACIN | 576 | 1.3% | 279 | 340 | 200 |
| FUROSEMIDE | 521 | 1.0% | 309 | 286 | 195 |
| VANCOMYCIN | 515 | 1.5% | 229 | 314 | 183 |
| PIPERACILLIN\TAZOBACTAM | 490 | 2.6% | 250 | 293 | 177 |
| PEMBROLIZUMAB | 444 | 0.5% | 211 | 309 | 118 |
| PANTOPRAZOLE | 401 | 0.5% | 221 | 226 | 164 |
| CEFTRIAXONE | 399 | 2.1% | 120 | 236 | 128 |
| AMOXICILLIN | 376 | 1.2% | 81 | 262 | 94 |
| LEVETIRACETAM | 357 | 0.6% | 86 | 226 | 113 |
| OMEPRAZOLE | 333 | 0.4% | 123 | 151 | 133 |
| METHOTREXATE | 319 | 0.1% | 181 | 159 | 88 |
| MEROPENEM | 312 | 2.3% | 129 | 174 | 100 |
| PREDNISOLONE | 290 | 0.4% | 139 | 191 | 120 |
| METHYLPREDNISOLONE | 276 | 0.4% | 124 | 195 | 129 |
| CARBAMAZEPINE | 275 | 1.1% | 67 | 180 | 92 |