Does NALMEFENE Cause Hepatotoxicity? 18 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 18 reports of Hepatotoxicity have been filed in association with NALMEFENE (Zurnai). This represents 9.1% of all adverse event reports for NALMEFENE.
18
Reports of Hepatotoxicity with NALMEFENE
9.1%
of all NALMEFENE reports
18
Deaths
10
Hospitalizations
How Dangerous Is Hepatotoxicity From NALMEFENE?
Of the 18 reports, 18 (100.0%) resulted in death, 10 (55.6%) required hospitalization.
Is Hepatotoxicity Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for NALMEFENE. However, 18 reports have been filed with the FAERS database.
What Other Side Effects Does NALMEFENE Cause?
Drug ineffective (66)
Coma (47)
Toxicity to various agents (43)
Hypotension (30)
Respiratory depression (25)
Depressed level of consciousness (19)
Acute kidney injury (15)
Drug withdrawal syndrome (15)
Metabolic acidosis (14)
Off label use (14)
What Other Drugs Cause Hepatotoxicity?
METHOTREXATE (1,917)
ACETAMINOPHEN (1,557)
LEFLUNOMIDE (829)
HYDROXYCHLOROQUINE (715)
PREDNISONE (707)
RITUXIMAB (702)
ETANERCEPT (699)
ADALIMUMAB (674)
CYCLOPHOSPHAMIDE (632)
SULFASALAZINE (613)
Which NALMEFENE Alternatives Have Lower Hepatotoxicity Risk?
NALMEFENE vs NALOXEGOL OXALATE
NALMEFENE vs NALOXONE
NALMEFENE vs NALOXONE\OXYCODONE
NALMEFENE vs NALOXONE\TILIDINE
NALMEFENE vs NALTREXONE