Does PEGASPARGASE Cause Encephalopathy? 72 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 72 reports of Encephalopathy have been filed in association with PEGASPARGASE (ONCASPAR). This represents 0.6% of all adverse event reports for PEGASPARGASE.
72
Reports of Encephalopathy with PEGASPARGASE
0.6%
of all PEGASPARGASE reports
21
Deaths
54
Hospitalizations
How Dangerous Is Encephalopathy From PEGASPARGASE?
Of the 72 reports, 21 (29.2%) resulted in death, 54 (75.0%) required hospitalization, and 22 (30.6%) were considered life-threatening.
Is Encephalopathy Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PEGASPARGASE. However, 72 reports have been filed with the FAERS database.
What Other Side Effects Does PEGASPARGASE Cause?
Febrile neutropenia (1,589)
Pyrexia (706)
Febrile bone marrow aplasia (668)
Sepsis (548)
Vomiting (530)
Neutropenia (521)
Abdominal pain (469)
Hypertriglyceridaemia (399)
Hypotension (388)
Thrombocytopenia (382)
What Other Drugs Cause Encephalopathy?
BACLOFEN (845)
METHOTREXATE (775)
ACETAMINOPHEN (608)
IFOSFAMIDE (585)
CYCLOPHOSPHAMIDE (552)
TACROLIMUS (523)
PREDNISONE (489)
DEXAMETHASONE (428)
METFORMIN (418)
ETOPOSIDE (404)
Which PEGASPARGASE Alternatives Have Lower Encephalopathy Risk?
PEGASPARGASE vs PEGASYS
PEGASPARGASE vs PEGCETACOPLAN
PEGASPARGASE vs PEGFILGRASTIM
PEGASPARGASE vs PEGFILGRASTIM-APGF
PEGASPARGASE vs PEGFILGRASTIM-BMEZ