Does PEGASPARGASE Cause Hepatic failure? 124 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 124 reports of Hepatic failure have been filed in association with PEGASPARGASE (ONCASPAR). This represents 1.1% of all adverse event reports for PEGASPARGASE.
124
Reports of Hepatic failure with PEGASPARGASE
1.1%
of all PEGASPARGASE reports
75
Deaths
80
Hospitalizations
How Dangerous Is Hepatic failure From PEGASPARGASE?
Of the 124 reports, 75 (60.5%) resulted in death, 80 (64.5%) required hospitalization, and 28 (22.6%) were considered life-threatening.
Is Hepatic failure Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PEGASPARGASE. However, 124 reports have been filed with the FAERS database.
What Other Side Effects Does PEGASPARGASE Cause?
Febrile neutropenia (1,589)
Pyrexia (706)
Febrile bone marrow aplasia (668)
Sepsis (548)
Vomiting (530)
Neutropenia (521)
Abdominal pain (469)
Hypertriglyceridaemia (399)
Hypotension (388)
Thrombocytopenia (382)
What Other Drugs Cause Hepatic failure?
ACETAMINOPHEN (1,392)
RIBAVIRIN (888)
CYCLOPHOSPHAMIDE (629)
METHOTREXATE (598)
BEVACIZUMAB (558)
SOFOSBUVIR (525)
RITUXIMAB (513)
VINCRISTINE (468)
DOXORUBICIN (462)
PREDNISOLONE (425)
Which PEGASPARGASE Alternatives Have Lower Hepatic failure Risk?
PEGASPARGASE vs PEGASYS
PEGASPARGASE vs PEGCETACOPLAN
PEGASPARGASE vs PEGFILGRASTIM
PEGASPARGASE vs PEGFILGRASTIM-APGF
PEGASPARGASE vs PEGFILGRASTIM-BMEZ