Does PEGASPARGASE Cause Osteonecrosis? 79 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 79 reports of Osteonecrosis have been filed in association with PEGASPARGASE (ONCASPAR). This represents 0.7% of all adverse event reports for PEGASPARGASE.
79
Reports of Osteonecrosis with PEGASPARGASE
0.7%
of all PEGASPARGASE reports
1
Deaths
22
Hospitalizations
How Dangerous Is Osteonecrosis From PEGASPARGASE?
Of the 79 reports, 1 (1.3%) resulted in death, 22 (27.8%) required hospitalization, and 2 (2.5%) were considered life-threatening.
Is Osteonecrosis Listed in the Official Label?
Yes, Osteonecrosis is listed as a known adverse reaction in the official FDA drug label for PEGASPARGASE.
What Other Side Effects Does PEGASPARGASE Cause?
Febrile neutropenia (1,589)
Pyrexia (706)
Febrile bone marrow aplasia (668)
Sepsis (548)
Vomiting (530)
Neutropenia (521)
Abdominal pain (469)
Hypertriglyceridaemia (399)
Hypotension (388)
Thrombocytopenia (382)
What Other Drugs Cause Osteonecrosis?
EMTRICITABINE\TENOFOVIR DISOPROXIL (8,935)
TENOFOVIR DISOPROXIL (7,182)
EFAVIRENZ\EMTRICITABINE\TENOFOVIR DISOPROXIL (4,338)
COBICISTAT\ELVITEGRAVIR\EMTRICITABINE\TENOFOVIR DISOPROXIL (2,081)
EMTRICITABINE\RILPIVIRINE\TENOFOVIR DISOPROXIL (1,492)
PREDNISONE (779)
PREDNISOLONE (711)
DENOSUMAB (567)
METHOTREXATE (563)
DEXAMETHASONE (531)
Which PEGASPARGASE Alternatives Have Lower Osteonecrosis Risk?
PEGASPARGASE vs PEGASYS
PEGASPARGASE vs PEGCETACOPLAN
PEGASPARGASE vs PEGFILGRASTIM
PEGASPARGASE vs PEGFILGRASTIM-APGF
PEGASPARGASE vs PEGFILGRASTIM-BMEZ