Does PONATINIB Cause Hyperammonaemia? 10 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 10 reports of Hyperammonaemia have been filed in association with PONATINIB (Iclusig). This represents 0.1% of all adverse event reports for PONATINIB.
10
Reports of Hyperammonaemia with PONATINIB
0.1%
of all PONATINIB reports
2
Deaths
10
Hospitalizations
How Dangerous Is Hyperammonaemia From PONATINIB?
Of the 10 reports, 2 (20.0%) resulted in death, 10 (100.0%) required hospitalization, and 8 (80.0%) were considered life-threatening.
Is Hyperammonaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PONATINIB. However, 10 reports have been filed with the FAERS database.
What Other Side Effects Does PONATINIB Cause?
Death (1,735)
Off label use (1,071)
Product dose omission issue (817)
Fatigue (687)
Rash (639)
Headache (553)
Pyrexia (542)
Nausea (466)
Hospitalisation (459)
Constipation (435)
What Other Drugs Cause Hyperammonaemia?
VALPROIC ACID (581)
VALPROATE (328)
FLUOROURACIL (263)
DIVALPROEX (256)
LEVETIRACETAM (192)
TACROLIMUS (181)
ACETAMINOPHEN (177)
OXALIPLATIN (160)
TOPIRAMATE (156)
GLYCEROL PHENYLBUTYRATE (147)
Which PONATINIB Alternatives Have Lower Hyperammonaemia Risk?
PONATINIB vs PONATINIB\PONATINIB
PONATINIB vs PONESIMOD
PONATINIB vs PORACTANT ALFA
PONATINIB vs PORFIMER
PONATINIB vs POSACONAZOLE