Does RUFINAMIDE Cause Hyperammonaemia? 15 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 15 reports of Hyperammonaemia have been filed in association with RUFINAMIDE (RUFINAMIDE). This represents 1.7% of all adverse event reports for RUFINAMIDE.
15
Reports of Hyperammonaemia with RUFINAMIDE
1.7%
of all RUFINAMIDE reports
0
Deaths
7
Hospitalizations
How Dangerous Is Hyperammonaemia From RUFINAMIDE?
Of the 15 reports, 7 (46.7%) required hospitalization.
Is Hyperammonaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for RUFINAMIDE. However, 15 reports have been filed with the FAERS database.
What Other Side Effects Does RUFINAMIDE Cause?
Drug ineffective (219)
Seizure (127)
Off label use (83)
Multiple-drug resistance (77)
Drug resistance (72)
Somnolence (70)
Status epilepticus (56)
Treatment failure (54)
Epilepsy (50)
Therapy non-responder (40)
What Other Drugs Cause Hyperammonaemia?
VALPROIC ACID (581)
VALPROATE (328)
FLUOROURACIL (263)
DIVALPROEX (256)
LEVETIRACETAM (192)
TACROLIMUS (181)
ACETAMINOPHEN (177)
OXALIPLATIN (160)
TOPIRAMATE (156)
GLYCEROL PHENYLBUTYRATE (147)
Which RUFINAMIDE Alternatives Have Lower Hyperammonaemia Risk?
RUFINAMIDE vs RUPATADINE
RUFINAMIDE vs RUXOLITINIB
RUFINAMIDE vs SABRIL
RUFINAMIDE vs SACCHAROMYCES CEREVISIAE
RUFINAMIDE vs SACITUZUMAB GOVITECAN