Does SPIRONOLACTONE Cause Hyperammonaemia? 6 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 6 reports of Hyperammonaemia have been filed in association with SPIRONOLACTONE (spironolactone). This represents 0.0% of all adverse event reports for SPIRONOLACTONE.
6
Reports of Hyperammonaemia with SPIRONOLACTONE
0.0%
of all SPIRONOLACTONE reports
3
Deaths
2
Hospitalizations
How Dangerous Is Hyperammonaemia From SPIRONOLACTONE?
Of the 6 reports, 3 (50.0%) resulted in death, 2 (33.3%) required hospitalization, and 1 (16.7%) were considered life-threatening.
Is Hyperammonaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for SPIRONOLACTONE. However, 6 reports have been filed with the FAERS database.
What Other Side Effects Does SPIRONOLACTONE Cause?
Acute kidney injury (3,273)
Hyperkalaemia (2,518)
Hypotension (1,583)
Dyspnoea (1,468)
Drug ineffective (1,379)
Hyponatraemia (1,166)
Dizziness (991)
Fatigue (990)
Fall (947)
Off label use (899)
What Other Drugs Cause Hyperammonaemia?
VALPROIC ACID (581)
VALPROATE (328)
FLUOROURACIL (263)
DIVALPROEX (256)
LEVETIRACETAM (192)
TACROLIMUS (181)
ACETAMINOPHEN (177)
OXALIPLATIN (160)
TOPIRAMATE (156)
GLYCEROL PHENYLBUTYRATE (147)
Which SPIRONOLACTONE Alternatives Have Lower Hyperammonaemia Risk?
SPIRONOLACTONE vs SPRYCEL
SPIRONOLACTONE vs STALEVO
SPIRONOLACTONE vs STANNOUS FLUORIDE
SPIRONOLACTONE vs STANOZOLOL
SPIRONOLACTONE vs STAVUDINE