Does SULFASALAZINE Cause Intestinal perforation? 59 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 59 reports of Intestinal perforation have been filed in association with SULFASALAZINE (Azulfidine EN-tabs). This represents 0.2% of all adverse event reports for SULFASALAZINE.
59
Reports of Intestinal perforation with SULFASALAZINE
0.2%
of all SULFASALAZINE reports
1
Deaths
20
Hospitalizations
How Dangerous Is Intestinal perforation From SULFASALAZINE?
Of the 59 reports, 1 (1.7%) resulted in death, 20 (33.9%) required hospitalization, and 10 (16.9%) were considered life-threatening.
Is Intestinal perforation Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for SULFASALAZINE. However, 59 reports have been filed with the FAERS database.
What Other Side Effects Does SULFASALAZINE Cause?
Drug ineffective (22,365)
Rheumatoid arthritis (15,136)
Drug intolerance (11,530)
Pain (11,309)
Fatigue (9,684)
Joint swelling (9,673)
Rash (8,739)
Contraindicated product administered (8,698)
Arthralgia (8,527)
Abdominal discomfort (8,404)
What Other Drugs Cause Intestinal perforation?
ADALIMUMAB (1,010)
BEVACIZUMAB (600)
RITUXIMAB (321)
TOCILIZUMAB (276)
PREDNISONE (266)
CYCLOPHOSPHAMIDE (262)
DOXORUBICIN (240)
LENVATINIB (228)
INFLIXIMAB (226)
PEMBROLIZUMAB (220)
Which SULFASALAZINE Alternatives Have Lower Intestinal perforation Risk?
SULFASALAZINE vs SULFATHIAZOLE
SULFASALAZINE vs SULFISOMIDINE
SULFASALAZINE vs SULFUR
SULFASALAZINE vs SULFUR HEXAFLUORIDE
SULFASALAZINE vs SULINDAC