Does TRAMETINIB Cause Intestinal perforation? 29 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 29 reports of Intestinal perforation have been filed in association with TRAMETINIB. This represents 0.5% of all adverse event reports for TRAMETINIB.
29
Reports of Intestinal perforation with TRAMETINIB
0.5%
of all TRAMETINIB reports
10
Deaths
15
Hospitalizations
How Dangerous Is Intestinal perforation From TRAMETINIB?
Of the 29 reports, 10 (34.5%) resulted in death, 15 (51.7%) required hospitalization, and 4 (13.8%) were considered life-threatening.
Is Intestinal perforation Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for TRAMETINIB. However, 29 reports have been filed with the FAERS database.
What Other Side Effects Does TRAMETINIB Cause?
Pyrexia (1,096)
Malignant neoplasm progression (807)
Product use in unapproved indication (349)
Diarrhoea (325)
Nausea (301)
Rash (290)
Vomiting (289)
Fatigue (269)
Death (240)
Chills (227)
What Other Drugs Cause Intestinal perforation?
ADALIMUMAB (1,010)
BEVACIZUMAB (600)
RITUXIMAB (321)
TOCILIZUMAB (276)
PREDNISONE (266)
CYCLOPHOSPHAMIDE (262)
DOXORUBICIN (240)
LENVATINIB (228)
INFLIXIMAB (226)
PEMBROLIZUMAB (220)
Which TRAMETINIB Alternatives Have Lower Intestinal perforation Risk?
TRAMETINIB vs TRAMETINIB DIMETHYL SULFOXIDE
TRAMETINIB vs TRANDOLAPRIL
TRAMETINIB vs TRANDOLAPRIL\VERAPAMIL
TRAMETINIB vs TRANEXAMIC ACID
TRAMETINIB vs TRANYLCYPROMINE