Does TRASTUZUMAB Cause Leukoencephalopathy? 26 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 26 reports of Leukoencephalopathy have been filed in association with TRASTUZUMAB (Trazimera). This represents 0.1% of all adverse event reports for TRASTUZUMAB.
26
Reports of Leukoencephalopathy with TRASTUZUMAB
0.1%
of all TRASTUZUMAB reports
11
Deaths
11
Hospitalizations
How Dangerous Is Leukoencephalopathy From TRASTUZUMAB?
Of the 26 reports, 11 (42.3%) resulted in death, 11 (42.3%) required hospitalization, and 3 (11.5%) were considered life-threatening.
Is Leukoencephalopathy Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for TRASTUZUMAB. However, 26 reports have been filed with the FAERS database.
What Other Side Effects Does TRASTUZUMAB Cause?
Diarrhoea (4,996)
Off label use (3,802)
Nausea (3,499)
Fatigue (3,417)
Myelosuppression (2,552)
Disease progression (2,449)
Death (2,378)
Vomiting (2,244)
Dyspnoea (2,010)
Pyrexia (1,886)
What Other Drugs Cause Leukoencephalopathy?
METHOTREXATE (717)
CYTARABINE (208)
VINCRISTINE (138)
CYCLOPHOSPHAMIDE (137)
RITUXIMAB (118)
DEXAMETHASONE (107)
FLUOROURACIL (103)
FLUDARABINE (89)
TACROLIMUS (79)
CAPECITABINE (77)
Which TRASTUZUMAB Alternatives Have Lower Leukoencephalopathy Risk?
TRASTUZUMAB vs TRASTUZUMAB-ANNS
TRASTUZUMAB vs TRASTUZUMAB DERUXTECAN
TRASTUZUMAB vs TRASTUZUMAB-DKST
TRASTUZUMAB vs TRASTUZUMAB-DTTB
TRASTUZUMAB vs TRASTUZUMAB EMTANSINE