Acute graft versus host disease: Which Medications Cause It? (2,976 Reports Across 146 Drugs)
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Acute graft versus host disease has been reported as an adverse event with 146 different drugs in the FDA's FAERS database, with 2,976 total reports. 1,030 of these reports resulted in death.The drugs most commonly associated with Acute graft versus host disease are CYCLOSPORINE, MYCOPHENOLATE MOFETIL, and FLUDARABINE.
2,976
Total Reports
146
Drugs Involved
1,030
Deaths
484
Hospitalizations
32.3 yrs
Average Patient Age
39.1% / 60.9%
Female / Male
Which Drugs Cause Acute graft versus host disease Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| CYCLOSPORINE | 1,043 | 1.5% | 352 | 142 | 41 |
| MYCOPHENOLATE MOFETIL | 1,021 | 1.4% | 325 | 125 | 38 |
| FLUDARABINE | 715 | 3.0% | 216 | 127 | 37 |
| CYCLOPHOSPHAMIDE | 710 | 0.6% | 199 | 105 | 27 |
| TACROLIMUS | 686 | 0.8% | 208 | 105 | 35 |
| METHOTREXATE | 656 | 0.3% | 183 | 93 | 28 |
| BUSULFAN | 337 | 3.0% | 117 | 80 | 17 |
| THIOTEPA | 331 | 4.8% | 98 | 36 | 19 |
| LAPINE T-LYMPHOCYTE IMMUNE GLOBULIN | 245 | 2.6% | 62 | 84 | 26 |
| RUXOLITINIB | 240 | 0.4% | 107 | 50 | 8 |
| MELPHALAN | 224 | 1.4% | 67 | 48 | 18 |
| METHYLPREDNISOLONE | 204 | 0.3% | 65 | 63 | 20 |
| RITUXIMAB | 190 | 0.1% | 44 | 50 | 8 |
| PREDNISOLONE | 162 | 0.2% | 43 | 43 | 10 |
| SIROLIMUS | 157 | 1.4% | 40 | 32 | 8 |
| THYMOCYTE IMMUNE GLOBULIN NOS | 143 | 2.6% | 68 | 25 | 9 |
| DEFIBROTIDE | 140 | 3.7% | 69 | 56 | 6 |
| PREDNISONE | 139 | 0.1% | 46 | 45 | 13 |
| BUDESONIDE | 117 | 0.5% | 51 | 8 | 7 |
| ETOPOSIDE | 104 | 0.2% | 23 | 24 | 6 |