Breakthrough pain: Which Medications Cause It? (1,405 Reports Across 70 Drugs)
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Breakthrough pain has been reported as an adverse event with 70 different drugs in the FDA's FAERS database, with 1,405 total reports. 34 of these reports resulted in death.The drugs most commonly associated with Breakthrough pain are FENTANYL, BUPRENORPHINE, and OXYCODONE.
1,405
Total Reports
70
Drugs Involved
34
Deaths
155
Hospitalizations
54.2 yrs
Average Patient Age
68.9% / 31.1%
Female / Male
Which Drugs Cause Breakthrough pain Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| FENTANYL | 259 | 0.3% | 5 | 21 | 0 |
| BUPRENORPHINE | 184 | 0.2% | 2 | 5 | 2 |
| OXYCODONE | 105 | 0.1% | 12 | 13 | 2 |
| MORPHINE | 59 | 0.1% | 9 | 16 | 0 |
| SECUKINUMAB | 59 | 0.0% | 0 | 2 | 0 |
| ETANERCEPT | 57 | 0.0% | 0 | 1 | 0 |
| ADALIMUMAB | 51 | 0.0% | 0 | 0 | 0 |
| PREGABALIN | 48 | 0.1% | 0 | 8 | 0 |
| TOFACITINIB | 47 | 0.0% | 0 | 3 | 0 |
| HYDROCODONE | 46 | 0.1% | 0 | 1 | 0 |
| GABAPENTIN | 39 | 0.1% | 0 | 4 | 0 |
| TAPENTADOL | 35 | 0.1% | 0 | 3 | 0 |
| CERTOLIZUMAB PEGOL | 27 | 0.0% | 0 | 0 | 0 |
| METHOTREXATE | 27 | 0.0% | 0 | 15 | 0 |
| CYCLOPHOSPHAMIDE | 25 | 0.0% | 0 | 15 | 0 |
| ACETAMINOPHEN\HYDROCODONE | 23 | 0.0% | 1 | 5 | 0 |
| PREDNISONE | 23 | 0.0% | 0 | 17 | 0 |
| HYDROMORPHONE | 22 | 0.0% | 2 | 8 | 1 |
| ACETAMINOPHEN\OXYCODONE | 20 | 0.0% | 2 | 4 | 0 |
| BACLOFEN | 20 | 0.1% | 0 | 2 | 0 |