Differentiation syndrome: Which Medications Cause It? (601 Reports Across 36 Drugs)
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Differentiation syndrome has been reported as an adverse event with 36 different drugs in the FDA's FAERS database, with 601 total reports. 111 of these reports resulted in death.The drugs most commonly associated with Differentiation syndrome are TRETINOIN, ARSENIC TRIOXIDE, and ENASIDENIB.
601
Total Reports
36
Drugs Involved
111
Deaths
311
Hospitalizations
55.6 yrs
Average Patient Age
48.4% / 51.6%
Female / Male
Which Drugs Cause Differentiation syndrome Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| TRETINOIN | 251 | 6.1% | 29 | 118 | 33 |
| ARSENIC TRIOXIDE | 180 | 15.3% | 14 | 87 | 13 |
| ENASIDENIB | 102 | 2.8% | 19 | 66 | 11 |
| GILTERITINIB | 80 | 2.2% | 24 | 38 | 8 |
| IVOSIDENIB | 80 | 4.7% | 22 | 46 | 14 |
| AZACITIDINE | 50 | 0.3% | 7 | 36 | 12 |
| HYDROXYUREA | 41 | 0.7% | 10 | 22 | 11 |
| DEXAMETHASONE | 38 | 0.0% | 18 | 19 | 17 |
| CYTARABINE | 33 | 0.1% | 4 | 23 | 3 |
| PREDNISONE | 25 | 0.0% | 8 | 16 | 9 |
| PIPERACILLIN\TAZOBACTAM | 24 | 0.1% | 1 | 21 | 3 |
| IDARUBICIN | 22 | 0.4% | 9 | 11 | 4 |
| AMLODIPINE | 19 | 0.0% | 6 | 13 | 6 |
| CASPOFUNGIN | 17 | 0.5% | 0 | 17 | 0 |
| LINEZOLID | 17 | 0.1% | 0 | 17 | 2 |
| FLUCONAZOLE | 16 | 0.1% | 0 | 13 | 0 |
| REVUMENIB | 16 | 4.3% | 3 | 4 | 0 |
| VENETOCLAX | 16 | 0.0% | 6 | 9 | 1 |
| SULFAMETHOXAZOLE\TRIMETHOPRIM | 14 | 0.0% | 0 | 14 | 0 |
| ALPRAZOLAM | 13 | 0.0% | 0 | 13 | 0 |