Gastric perforation: Which Medications Cause It? (1,961 Reports Across 134 Drugs)
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Gastric perforation has been reported as an adverse event with 134 different drugs in the FDA's FAERS database, with 1,961 total reports. 358 of these reports resulted in death.The drugs most commonly associated with Gastric perforation are IBUPROFEN, BEVACIZUMAB, and ADALIMUMAB.
1,961
Total Reports
134
Drugs Involved
358
Deaths
1,212
Hospitalizations
59.2 yrs
Average Patient Age
50.0% / 50.0%
Female / Male
Which Drugs Cause Gastric perforation Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| IBUPROFEN | 113 | 0.1% | 6 | 86 | 33 |
| BEVACIZUMAB | 110 | 0.1% | 27 | 55 | 19 |
| ADALIMUMAB | 97 | 0.0% | 4 | 57 | 2 |
| CARBIDOPA\LEVODOPA | 81 | 0.1% | 18 | 63 | 7 |
| PREDNISONE | 70 | 0.0% | 26 | 43 | 8 |
| CISPLATIN | 68 | 0.1% | 9 | 38 | 7 |
| OXALIPLATIN | 68 | 0.1% | 17 | 42 | 17 |
| DEXAMETHASONE | 66 | 0.1% | 16 | 55 | 20 |
| CAPECITABINE | 64 | 0.1% | 11 | 33 | 12 |
| RITUXIMAB | 59 | 0.0% | 17 | 34 | 12 |
| DICLOFENAC | 53 | 0.1% | 6 | 38 | 11 |
| CYCLOPHOSPHAMIDE | 52 | 0.0% | 14 | 33 | 6 |
| LENVATINIB | 51 | 0.2% | 13 | 34 | 6 |
| DOXORUBICIN | 49 | 0.1% | 13 | 25 | 3 |
| PACLITAXEL | 49 | 0.1% | 14 | 34 | 10 |
| RAMUCIRUMAB | 49 | 0.9% | 22 | 33 | 16 |
| PEMBROLIZUMAB | 46 | 0.1% | 15 | 26 | 9 |
| TOCILIZUMAB | 46 | 0.1% | 6 | 15 | 3 |
| NAPROXEN | 45 | 0.1% | 14 | 18 | 9 |
| FLUOROURACIL | 44 | 0.1% | 14 | 20 | 6 |