Immune-mediated myocarditis: Which Medications Cause It? (1,256 Reports Across 41 Drugs)
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Immune-mediated myocarditis has been reported as an adverse event with 41 different drugs in the FDA's FAERS database, with 1,256 total reports. 360 of these reports resulted in death.The drugs most commonly associated with Immune-mediated myocarditis are PEMBROLIZUMAB, NIVOLUMAB, and IPILIMUMAB.
1,256
Total Reports
41
Drugs Involved
360
Deaths
822
Hospitalizations
66.4 yrs
Average Patient Age
38.2% / 61.8%
Female / Male
Which Drugs Cause Immune-mediated myocarditis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| PEMBROLIZUMAB | 599 | 0.7% | 176 | 400 | 128 |
| NIVOLUMAB | 444 | 0.5% | 122 | 294 | 163 |
| IPILIMUMAB | 248 | 0.7% | 63 | 162 | 88 |
| CARBOPLATIN | 93 | 0.1% | 18 | 68 | 22 |
| DURVALUMAB | 74 | 0.4% | 29 | 45 | 25 |
| LENVATINIB | 66 | 0.2% | 13 | 47 | 9 |
| DOXORUBICIN | 59 | 0.1% | 4 | 12 | 4 |
| PACLITAXEL | 58 | 0.1% | 11 | 41 | 9 |
| PEMETREXED | 43 | 0.2% | 13 | 34 | 16 |
| ATEZOLIZUMAB | 37 | 0.1% | 7 | 20 | 1 |
| BEVACIZUMAB | 32 | 0.0% | 5 | 13 | 2 |
| METHYLPREDNISOLONE | 29 | 0.1% | 9 | 23 | 12 |
| CISPLATIN | 27 | 0.1% | 8 | 23 | 7 |
| AXITINIB | 22 | 0.1% | 8 | 19 | 4 |
| FLUOROURACIL | 21 | 0.0% | 4 | 14 | 2 |
| OXALIPLATIN | 21 | 0.0% | 4 | 17 | 1 |
| CYCLOPHOSPHAMIDE | 20 | 0.0% | 4 | 9 | 0 |
| GEMCITABINE | 20 | 0.1% | 4 | 16 | 2 |
| SINTILIMAB | 19 | 2.9% | 5 | 8 | 2 |
| DOCETAXEL | 15 | 0.0% | 5 | 13 | 2 |