Local anaesthetic systemic toxicity: Which Medications Cause It? (735 Reports Across 28 Drugs)
Boost Your Natural Energy & Metabolism
Mitolyn — 6 exotic plants to unlock your body's fat-burning power. 90-day guarantee.
Local anaesthetic systemic toxicity has been reported as an adverse event with 28 different drugs in the FDA's FAERS database, with 735 total reports. 38 of these reports resulted in death.The drugs most commonly associated with Local anaesthetic systemic toxicity are LIDOCAINE, BUPIVACAINE, and ROPIVACAINE.
735
Total Reports
28
Drugs Involved
38
Deaths
512
Hospitalizations
49.3 yrs
Average Patient Age
59.5% / 40.5%
Female / Male
Which Drugs Cause Local anaesthetic systemic toxicity Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| LIDOCAINE | 511 | 2.3% | 22 | 364 | 250 |
| BUPIVACAINE | 188 | 1.7% | 6 | 118 | 99 |
| ROPIVACAINE | 109 | 3.7% | 8 | 73 | 42 |
| EPINEPHRINE | 59 | 0.4% | 1 | 42 | 25 |
| PROPOFOL | 23 | 0.1% | 4 | 20 | 16 |
| EPINEPHRINE\LIDOCAINE | 19 | 0.8% | 0 | 12 | 6 |
| FENTANYL | 18 | 0.0% | 0 | 11 | 9 |
| KETAMINE | 12 | 0.2% | 1 | 10 | 7 |
| MEPIVACAINE | 11 | 1.6% | 0 | 5 | 6 |
| MIDAZOLAM | 11 | 0.1% | 2 | 8 | 3 |
| REMIFENTANIL | 11 | 0.4% | 1 | 10 | 6 |
| METOPROLOL | 10 | 0.0% | 0 | 9 | 0 |
| NOREPINEPHRINE | 9 | 0.2% | 0 | 7 | 7 |
| BUPROPION | 8 | 0.0% | 0 | 7 | 0 |
| LIDOCAINE ANHYDROUS | 8 | 12.9% | 0 | 8 | 5 |
| AMIODARONE | 7 | 0.0% | 2 | 5 | 2 |
| EGG PHOSPHOLIPIDS\SAFFLOWER OIL\SOYBEAN OIL | 7 | 3.6% | 6 | 5 | 0 |
| NITRIC | 7 | 0.2% | 0 | 7 | 0 |
| VASOPRESSIN | 7 | 0.4% | 0 | 6 | 6 |
| DIVALPROEX | 6 | 0.1% | 0 | 6 | 0 |