Malignant transformation: Which Medications Cause It? (409 Reports Across 51 Drugs)
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Malignant transformation has been reported as an adverse event with 51 different drugs in the FDA's FAERS database, with 409 total reports. 142 of these reports resulted in death.The drugs most commonly associated with Malignant transformation are OSIMERTINIB, ETOPOSIDE, and MELPHALAN.
409
Total Reports
51
Drugs Involved
142
Deaths
48
Hospitalizations
56.0 yrs
Average Patient Age
44.6% / 55.4%
Female / Male
Which Drugs Cause Malignant transformation Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| OSIMERTINIB | 109 | 0.4% | 19 | 5 | 1 |
| ETOPOSIDE | 108 | 0.2% | 67 | 5 | 0 |
| MELPHALAN | 95 | 0.6% | 63 | 0 | 0 |
| CYTARABINE | 91 | 0.2% | 58 | 0 | 0 |
| CARMUSTINE | 88 | 2.6% | 58 | 0 | 0 |
| CYCLOPHOSPHAMIDE | 73 | 0.1% | 53 | 4 | 2 |
| PREDNISONE | 69 | 0.0% | 54 | 5 | 0 |
| GEFITINIB | 67 | 1.4% | 10 | 4 | 1 |
| VINCRISTINE | 66 | 0.1% | 50 | 4 | 2 |
| DOXORUBICIN | 61 | 0.1% | 48 | 2 | 0 |
| IFOSFAMIDE | 60 | 0.4% | 47 | 5 | 0 |
| CISPLATIN | 58 | 0.1% | 41 | 5 | 0 |
| DEXAMETHASONE | 57 | 0.1% | 50 | 0 | 0 |
| RITUXIMAB | 56 | 0.0% | 37 | 0 | 0 |
| METHOTREXATE | 52 | 0.0% | 44 | 0 | 0 |
| FLUDARABINE | 33 | 0.1% | 22 | 0 | 0 |
| PROCARBAZINE | 31 | 0.5% | 24 | 2 | 2 |
| CHLORAMBUCIL | 25 | 1.1% | 21 | 0 | 0 |
| LEUPROLIDE | 24 | 0.0% | 1 | 1 | 0 |
| ALLOPURINOL | 23 | 0.1% | 0 | 0 | 0 |