Methaemoglobinaemia: Which Medications Cause It? (1,608 Reports Across 126 Drugs)
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Methaemoglobinaemia has been reported as an adverse event with 126 different drugs in the FDA's FAERS database, with 1,608 total reports. 151 of these reports resulted in death.The drugs most commonly associated with Methaemoglobinaemia are DAPSONE, LIDOCAINE, and ACETAMINOPHEN.
1,608
Total Reports
126
Drugs Involved
151
Deaths
1,089
Hospitalizations
45.9 yrs
Average Patient Age
45.2% / 54.8%
Female / Male
Which Drugs Cause Methaemoglobinaemia Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| DAPSONE | 322 | 9.7% | 13 | 242 | 48 |
| LIDOCAINE | 221 | 1.0% | 19 | 134 | 75 |
| ACETAMINOPHEN | 186 | 0.1% | 37 | 152 | 34 |
| BENZOCAINE | 162 | 29.6% | 13 | 88 | 59 |
| RASBURICASE | 92 | 10.4% | 8 | 70 | 10 |
| SULFAMETHOXAZOLE\TRIMETHOPRIM | 86 | 0.2% | 2 | 72 | 19 |
| LIDOCAINE\PRILOCAINE | 67 | 13.1% | 0 | 50 | 21 |
| PRIMAQUINE | 56 | 30.3% | 4 | 35 | 6 |
| HYDROXYCHLOROQUINE | 54 | 0.1% | 4 | 42 | 13 |
| MEROPENEM | 46 | 0.3% | 0 | 40 | 5 |
| PHENAZOPYRIDINE | 46 | 9.3% | 1 | 42 | 14 |
| IBUPROFEN | 40 | 0.1% | 11 | 35 | 11 |
| GABAPENTIN | 36 | 0.1% | 0 | 31 | 3 |
| PREDNISONE | 35 | 0.0% | 4 | 24 | 5 |
| DOXYCYCLINE | 31 | 0.2% | 0 | 25 | 1 |
| OXYCODONE | 30 | 0.0% | 0 | 27 | 2 |
| CALCIUM | 26 | 0.2% | 4 | 26 | 0 |
| PROPOFOL | 26 | 0.2% | 2 | 23 | 1 |
| TACROLIMUS | 26 | 0.0% | 0 | 11 | 1 |
| BUPROPION | 25 | 0.1% | 5 | 24 | 1 |