Mitochondrial dna mutation: Which Medications Cause It? (67 Reports Across 17 Drugs)
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Mitochondrial dna mutation has been reported as an adverse event with 17 different drugs in the FDA's FAERS database, with 67 total reports. 38 of these reports resulted in death.The drugs most commonly associated with Mitochondrial dna mutation are VALPROIC ACID, LACOSAMIDE, and LEVETIRACETAM.
67
Total Reports
17
Drugs Involved
38
Deaths
37
Hospitalizations
28.4 yrs
Average Patient Age
80.6% / 19.4%
Female / Male
Which Drugs Cause Mitochondrial dna mutation Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| VALPROIC ACID | 38 | 0.2% | 36 | 27 | 21 |
| LACOSAMIDE | 35 | 0.2% | 34 | 27 | 21 |
| LEVETIRACETAM | 35 | 0.1% | 34 | 26 | 21 |
| PROPOFOL | 34 | 0.2% | 33 | 27 | 21 |
| DEXAMETHASONE | 33 | 0.0% | 33 | 26 | 21 |
| ISOFLURANE | 33 | 4.0% | 33 | 26 | 21 |
| KETAMINE | 33 | 0.4% | 33 | 26 | 21 |
| MIDAZOLAM | 33 | 0.3% | 32 | 26 | 20 |
| PENTOBARBITAL | 33 | 7.4% | 33 | 26 | 21 |
| TOPIRAMATE | 33 | 0.1% | 33 | 26 | 21 |
| CLOBAZAM | 32 | 0.3% | 32 | 25 | 21 |
| MAGNESIUM | 32 | 0.3% | 32 | 25 | 20 |
| OXCARBAZEPINE | 32 | 0.3% | 32 | 25 | 20 |
| HUMAN IMMUNOGLOBULIN G | 23 | 0.0% | 23 | 21 | 17 |
| LORAZEPAM | 21 | 0.1% | 21 | 21 | 21 |
| PHENYTOIN | 11 | 0.1% | 11 | 11 | 11 |
| IMMUNE GLOBULIN NOS | 6 | 0.3% | 6 | 5 | 2 |