Mitochondrial toxicity: Which Medications Cause It? (543 Reports Across 64 Drugs)
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Mitochondrial toxicity has been reported as an adverse event with 64 different drugs in the FDA's FAERS database, with 543 total reports. 27 of these reports resulted in death.The drugs most commonly associated with Mitochondrial toxicity are LAMIVUDINE, STAVUDINE, and ZIDOVUDINE.
543
Total Reports
64
Drugs Involved
27
Deaths
157
Hospitalizations
48.8 yrs
Average Patient Age
32.2% / 67.8%
Female / Male
Which Drugs Cause Mitochondrial toxicity Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| LAMIVUDINE | 188 | 1.1% | 3 | 10 | 2 |
| STAVUDINE | 180 | 6.9% | 1 | 3 | 3 |
| ZIDOVUDINE | 177 | 2.6% | 0 | 6 | 0 |
| DIDANOSINE | 174 | 8.4% | 2 | 3 | 2 |
| NEVIRAPINE | 174 | 2.6% | 0 | 6 | 0 |
| SAQUINAVIR | 165 | 20.8% | 0 | 1 | 1 |
| TENOFOVIR DISOPROXIL | 161 | 0.6% | 0 | 6 | 1 |
| INDINAVIR | 156 | 21.4% | 0 | 0 | 0 |
| LOPINAVIR\RITONAVIR | 151 | 1.8% | 0 | 1 | 0 |
| ENFUVIRTIDE | 149 | 19.7% | 1 | 1 | 0 |
| ABACAVIR | 121 | 2.8% | 2 | 3 | 1 |
| RITONAVIR | 95 | 0.8% | 1 | 3 | 1 |
| EFAVIRENZ | 92 | 1.2% | 0 | 0 | 0 |
| RALTEGRAVIR | 89 | 1.0% | 1 | 1 | 1 |
| NELFINAVIR | 86 | 7.4% | 0 | 1 | 0 |
| DELAVIRDINE | 83 | 58.5% | 0 | 0 | 0 |
| ETRAVIRINE | 82 | 4.2% | 1 | 1 | 0 |
| LOPINAVIR | 82 | 6.6% | 0 | 0 | 0 |
| ATAZANAVIR | 78 | 1.4% | 1 | 2 | 0 |
| DARUNAVIR | 78 | 2.2% | 0 | 0 | 0 |