Pathological fracture: Which Medications Cause It? (3,302 Reports Across 192 Drugs)
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Pathological fracture has been reported as an adverse event with 192 different drugs in the FDA's FAERS database, with 3,302 total reports. 364 of these reports resulted in death.The drugs most commonly associated with Pathological fracture are DENOSUMAB, LENALIDOMIDE, and DEXAMETHASONE.
3,302
Total Reports
192
Drugs Involved
364
Deaths
1,452
Hospitalizations
62.3 yrs
Average Patient Age
66.5% / 33.5%
Female / Male
Which Drugs Cause Pathological fracture Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| DENOSUMAB | 634 | 0.4% | 59 | 146 | 3 |
| LENALIDOMIDE | 260 | 0.1% | 27 | 144 | 1 |
| DEXAMETHASONE | 201 | 0.2% | 45 | 120 | 15 |
| ALENDRONATE | 200 | 0.7% | 4 | 139 | 0 |
| ZOLEDRONIC ACID | 185 | 0.6% | 34 | 69 | 2 |
| RISEDRONATE | 110 | 1.6% | 2 | 65 | 0 |
| ADALIMUMAB | 93 | 0.0% | 3 | 23 | 1 |
| LETROZOLE | 87 | 0.3% | 5 | 43 | 2 |
| RITUXIMAB | 87 | 0.1% | 4 | 27 | 1 |
| CYCLOPHOSPHAMIDE | 85 | 0.1% | 13 | 37 | 3 |
| POMALIDOMIDE | 85 | 0.1% | 10 | 47 | 2 |
| BORTEZOMIB | 84 | 0.2% | 20 | 46 | 1 |
| METHOTREXATE | 84 | 0.0% | 13 | 31 | 1 |
| PREDNISONE | 83 | 0.1% | 8 | 37 | 4 |
| EMTRICITABINE\TENOFOVIR DISOPROXIL | 80 | 0.2% | 2 | 6 | 0 |
| NIVOLUMAB | 76 | 0.1% | 26 | 50 | 6 |
| PALBOCICLIB | 76 | 0.1% | 5 | 28 | 2 |
| ZOMETA | 71 | 8.2% | 25 | 51 | 1 |
| IBANDRONATE | 68 | 0.7% | 2 | 44 | 1 |
| TENOFOVIR DISOPROXIL | 62 | 0.2% | 1 | 14 | 0 |